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Форум гильдии Assassins of Lordaeron » Классовый Форум » Druid » Ферал билд по моему мнению оптимален...
Ферал билд по моему мнению оптимален...
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CshopjixДата: Вторник, 17 Декабря 2013, 22:56 | Сообщение # 167
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Docetaxel is of the chemotherapy pharmaceutical savoir vivre; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an extract from the bark of the rare Pacific yew tree Taxus brevifolia.[2 - Apt to dearth of paclitaxel, vast study was carried peripheral exhausted foremost to the formulation of docetaxel – an esterified yield of 10-deacetyl baccatin III, which is extracted from the renewable and gladly at one's disposal European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl functional dispose on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side gyve instead of the benzyl amide in paclitaxel. The carbon 10 functional sort revolution causes docetaxel to be more water soluble than paclitaxel.[2 -
Formulations and compositions
Docetaxel is a pure right and is the active ingredient at one's disposal in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.[2 - [8 - The answer is a readable brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.[8 - 20 mg Taxotere is distributed in a blister carton containing one single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL infecund pyrogen-free anhydrous polysorbate 80, and a distinct dose Taxotere creditworthy vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion bag containing 0.9% sodium chloride or 5% glucose after administration.[8 - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and financially sound vials are combined to pay a solution of 10 mg/mL and the required measure is drawn from this solution. Vials have an overfill to balance for solvent harm during preparation, foaming, adhesion to vial walls and the numb volume. 20 mg vials may be stored to 24 months under 25 °C away from understanding and 80 mg vials for 26 months in the yet conditions.[8 -
Recently Sanofi has got sanction in behalf of one-vial formulation.[citation needed - With this one-vial formulation, the preparation of the infusion answer is simplified alongside eliminating the first dilution step. The two-vial and one-vial formulations in the at any rate drug substance, docetaxel trihydrate, and the same excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous settling that contains the same drug nub in the selfsame concentration as the already approved two-vial formulation. The unmodified station, superiority, and measure of polysorbate 80 are present in the infusion elucidation of both formulations. The only difference between these two formulations is the measure of ethanol.
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